Počet záznamů: 1
Lime is a new protein linking immunity and metabolism in Drosophila
- 1.0506482 - BC 2020 RIV US eng J - Článek v odborném periodiku
Mihajlović, Zorana - Tanasic, D. - Bajgar, Adam - Perez-Gomez, Raquel - Steffal, P. - Krejčí, Alena
Lime is a new protein linking immunity and metabolism in Drosophila.
Developmental Biology. Roč. 452, č. 2 (2019), s. 83-94. ISSN 0012-1606. E-ISSN 1095-564X
Grant CEP: GA ČR(CZ) GA17-17529S
Institucionální podpora: RVO:60077344
Klíčová slova: CG184446 * Drosophila * metabolism
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 2.896, rok: 2019
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S0012160618305815?via%3Dihub
The proliferation, differentiation and function of immune cells in vertebrates, as well as in the invertebrates, is regulated by distinct signalling pathways and crosstalk with systemic and cellular metabolism. We have identified the Lime gene (Linking Immunity and Metabolism, CG18446) as one such connecting factor, linking hemocyte development with systemic metabolism in Drosophila. Lime is expressed in larval plasmatocytes and the fat body and regulates immune cell type and number by influencing the size of hemocyte progenitor populations in the lymph gland and in circulation. Lime mutant larvae exhibit low levels of glycogen and trehalose energy reserves and they develop low number of hemocytes. The low number of hemocytes in Lime mutants can be rescued by Lime overexpression in the fat body. It is well known that immune cell metabolism is tightly regulated with the progress of infection and it must be supported by systemic metabolic changes. Here we demonstrate that Lime mutants fails to induce such systemic metabolic changes essential for the larval immune response. Indeed, Lime mutants are not able to sustain high numbers of circulating hemocytes and are compromised in the number of lamellocytes produced during immune system challenge, using a parasitic wasp infection model. We therefore propose the Lime gene as a novel functional link between systemic metabolism and Drosophila immunity.
Trvalý link: http://hdl.handle.net/11104/0297710
Počet záznamů: 1