Počet záznamů: 1
The role of high cell density in the promotion of neuroendocrine transdifferentiation of prostate cancer cells
- 1.0506380 - BFÚ 2020 RIV GB eng J - Článek v odborném periodiku
Pernicová, Zuzana - Slabáková, Eva - Fedr, Radek - Šimečková, Šárka - Jaroš, J. - Suchánková, Tereza - Bouchal, J. - Kharaishvili, G. - Král, M. - Kozubík, Alois - Souček, Karel
The role of high cell density in the promotion of neuroendocrine transdifferentiation of prostate cancer cells.
Molecular Cancer. Roč. 13, MAY 20 2014 (2014), č. článku 113. E-ISSN 1476-4598
Grant CEP: GA ČR GPP301/12/P407
Institucionální podpora: RVO:68081707
Klíčová slova: Neuroendocrine transdifferentiation * Androgen depletion * High cell density * Cell cycle arrest * cAMP signaling
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 4.257, rok: 2014
Způsob publikování: Open access
https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/1476-4598-13-113
Background: Tumor heterogeneity and the plasticity of cancer cells present challenges for effective clinical diagnosis and therapy. Such challenges are epitomized by neuroendocrine transdifferentiation (NED) and the emergence of neuroendocrine-like cancer cells in prostate tumors. This phenomenon frequently arises from androgen-depleted prostate adenocarcinoma and is associated with the development of castration-resistant prostate cancer and poor prognosis.
Trvalý link: http://hdl.handle.net/11104/0297630
Počet záznamů: 1