Method of Solid-State Peptide Synthesis Using a Novel Poymeric Support.

0505926 - ÚCHP 2024 eng P - Patentový dokument
Jeřábek, Karel - Hanková, Libuše - Holub, Ladislav - Zecca, M. - Centomo, P. - Trovo, D. - Leder, R. - Biondi, B.
Method of Solid-State Peptide Synthesis Using a Novel Poymeric Support.
2018. Vlastník: Institute of Chemical Process Fundamentals of the CAS, v. v. i . - Universita degli Studi di Padova. Datum udělení patentu: 26.03.2018. Číslo patentu: EP18164049 A
Institucionální podpora: RVO:67985858
Klíčová slova: solid-state synthesis of peptides * styrenic polymer * amino acid
Obor OECD: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/061868172/publication/EP3546486A1?q=EP18164049

A method of solid-state synthesis of peptides that provides a polymeric solid-state synthesis support, attaches a first amino acid to said support to form the first amino acid 5 mole-cule of the desired peptide chain, attaches additional amino acids to form the desired peptide chain, characterized in that the polymeric solid-state synthesis support is a styrenic polymer containing at least 50 mol % divinylbenzene monomer units, the styrenic polymer being functionalized with chloromethyl and/or benzyloxybenzyl alcohol and/or amino moieties, and having porosity 60 - 90 % and medium pore diameter ranging from 10 to 80 nm .10 A functionalized styrenic polymer is claimed.
Trvalý link: http://hdl.handle.net/11104/0329423