Hydrogel tissue expanders for stomatology. Part II. poly(styrene-maleic anhydride) hydrogels

0505916 - ÚMCH 2020 RIV CH eng J - Článek v odborném periodiku
Hrib, Jakub - Chylíková Krumbholcová, Eva - Dušková-Smrčková, Miroslava - Hobzová, Radka - Širc, Jakub - Hrubý, Martin - Michálek, Jiří - Hodan, Jiří - Lesný, P. - Šmucler, R.
Hydrogel tissue expanders for stomatology. Part II. poly(styrene-maleic anhydride) hydrogels.
Polymers. Roč. 11, č. 7 (2019), s. 1-15, č. článku 1087. E-ISSN 2073-4360
Grant CEP: GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR(CZ) GA19-01602S
Institucionální podpora: RVO:61389013
Klíčová slova: hydrogel * self-inflating tissue expander * styrene-maleic anhydride copolymers
Obor OECD: Polymer science
Impakt faktor: 3.426, rok: 2019
Způsob publikování: Open access
https://www.mdpi.com/2073-4360/11/7/1087/pdf

Self-inflating soft tissue expanders represent a valuable modality in reconstructive surgery. For this purpose, particularly synthetic hydrogels that increase their volume by swelling in aqueous environment are used. The current challenge in the field is to deliver a material with a suitable protracted swelling response, ideally with an induction period (for sutured wound healing) followed by a linear increase in volume lasting several days for required tissue reconstruction. Here, we report on synthesis, swelling, thermal, mechanical and biological properties of novel hydrogel tissue expanders based on poly(styrene-alt-maleic anhydride) copolymers covalently crosslinked with p-divinylbenzene. The hydrogels exerted hydrolysis-driven swelling response with induction period over the first two days with minimal volume change and gradual volume growth within 30 days in buffered saline solution. Their final swollen volume reached more than 14 times the dry volume with little dependence on the crosslinker content. The mechanical coherence of samples during swelling and in their fully swollen state was excellent, the compression modulus of elasticity being between 750 and 850 kPa. In vitro cell culture experiments and in vivo evaluation in mice models showed excellent biocompatibility and suitable swelling responses meeting thus the application requirements as soft tissue expanders.
Trvalý link: http://hdl.handle.net/11104/0297619