Dipeptidyl peptidase IV expression in thyroid cytology: retrospective histologically confirmed study

0505371 - ÚI 2020 eng J - Článek v odborném periodiku
Kholová, I. - Ryška, A. - Ludvíková, M. - Čáp, J. - Pecen, Ladislav
Dipeptidyl peptidase IV expression in thyroid cytology: retrospective histologically confirmed study.
Cytopathology. Roč. 14, č. 1 (2003), s. 27-31. ISSN 0956-5507. E-ISSN 1365-2303
Klíčová slova: fine-needle aspiration * aminopeptidase-iv * monoclonal-antibody * management * carcinoma * biopsy * cd26 * diagnosis * diseases * nodule * dipeptidyl peptidase IV * cytology * cytochemistry * thyroid gland tumour * differential diagnosis
Impakt faktor: 1.011, rok: 2003
Způsob publikování: Omezený přístup

Fine needle aspiration cytology (FNAC) of the thyroid gland is a well-established method. However, it has inherent limitations, especially in the diagnosis of follicular and oncocytic tumours and in distinguishing between nuclear atypia in colloid goitre with regressive changes and cystic papillary carcinoma. The aim of our study was to evaluate dipeptidyl peptidase IV (DPP IV) as a marker of malignancy in FNAC. We tested 254 thyroid specimens (intraoperative imprint smears) for DPP IV. The sensitivity was 71%, the specificity was 96%, and the diagnostic accuracy was 93%, respectively, with a threshold of 50% of positive cells. To the best of our knowledge it is the largest histologically confirmed study reported in the literature. We suggest the assessment of DPP IV as an adjunct diagnostic marker of malignancy in thyroid specimens suspicious of papillary carcinoma. However, the value of the marker in follicular lesions is very limited.
Trvalý link: http://hdl.handle.net/11104/0296817