Expression of gamma-tubulin in non-small cell lung cancer and effect on patient survival

0505232 - ÚMG 2020 RIV ES eng J - Článek v odborném periodiku
Maounis, N.F. - Dráberová, Eduarda - Trakas, N. - Chorti, M. - Riga, D. - Tzannis, K. - Kanakis, M. - Voralu, K. - Ellina, E. - Mahera, E. - Demonakou, M. - Lioulias, A. - Dráber, Pavel - Katsetos, C.D.
Expression of gamma-tubulin in non-small cell lung cancer and effect on patient survival.
Histology and Histopathology. Roč. 34, č. 1 (2019), s. 81-90. ISSN 0213-3911. E-ISSN 1699-5848
Grant CEP: GA MŠMT(CZ) LTAUSA17052; GA ČR(CZ) GA17-11898S
Institucionální podpora: RVO:68378050
Klíčová slova: Gamma-tubulin * Immunohistochemistry * Non-small cell lung cancer * Survival
Obor OECD: Oncology
Impakt faktor: 2.021, rok: 2019
Způsob publikování: Omezený přístup
https://www.hh.um.es/Abstracts/Vol_34/34_1/34_1_81.htm

Introduction. It has been reported that overexpression and altered compartmentalization of gamma-tubulin may contribute to tumorigenesis and tumor aggressiveness in a variety of human malignancies. We have shown that gamma-tubulin expression and cellular distribution pattern is also altered in non-small cell lung cancer (NSCLC) (Histol. Histopathol. 2012, 27: 11831194). In the present study we examined the relationship between gamma-tubulin expression and patient overall survival (OS). Material and methods. Immunohistochemistry was performed, with well-characterized anti-gamma-tubulin antibodies, on 109 formalin-fixed, paraffin-embedded NSCLC specimens (p-TNM stage I-III). gamma-Tubulin labeling indexes (LIs) were determined, and the association of gamma-tubulin expression with clinicopathological parameters was evaluated. To analyze OS rates according to gamma-tubulin LIs, patients were categorized into three groups: those with low (0-30%), intermediate (31-69%) or high (70-100%) gamma-tubulin LI. Association of clinicopathological parameters and gamma-tubulin with survival were examined using univariate and multivariate Cox regression analysis. Results. No statistically significant association was seen between gamma-tubulin overexpression and histological type, tumor differentiation, p-TNM stage and adenocarcinoma subtyping. Longer survival was observed in the high gamma-tubulin LI group of patients with p-TNM stages II+III when compared to intermediate or low gamma-tubulin LI groups, but the difference was not statistically significant (p=0.066). On the other hand, when combined low and intermediate gamma-tubulin LI groups (p-TNM stages II+III) where compared to high gamma-tubulin LI group, statistically significant longer survival was observed in high gamma-tubulin group (p=0.021). Conclusion. Our findings suggest that level of gamma-tubulin expression may have an impact on patient survival at more advanced NSCLC stages.
Trvalý link: http://hdl.handle.net/11104/0296716