Molecular Functionalization of Planar Nanocrystalline and Porous Nanostructured Diamond to Form an Interface with Newborn and Adult Neurons

0504644 - FGÚ 2020 RIV DE eng J - Článek v odborném periodiku
Krůšek, Jan - Dittert, Ivan - Smejkalová, Tereza - Kořínek, Miloslav - Gottfriedová, K. - Freislebenová, Hana - Neuhöferová, Eva - Klimša, Ladislav - Sedláková, Silvia - Taylor, Andrew - Mortet, Vincent - Petrák, V. - Benson, Veronika - Petráková, V.
Molecular Functionalization of Planar Nanocrystalline and Porous Nanostructured Diamond to Form an Interface with Newborn and Adult Neurons.
Physica Status Solidi B. Roč. 256, č. 3 (2019), s. 1800424. ISSN 0370-1972. E-ISSN 1521-3951
Grant CEP: GA ČR(CZ) GA17-15319S; GA MŠMT(CZ) LM2015088; GA MŠMT(CZ) LO1409; GA MŠMT EF16_013/0001406; GA AV ČR(CZ) Fellowship J. E. Purkyně
Grant ostatní: AV ČR(CZ) Fellowship J. E. Purkyně; OP VVV - SAFMAT(XE) CZ.02.1.01/0.0/0.0/16_013/0001406
Program: Fellowship J. E. Purkyně
Výzkumná infrastruktura: SAFMAT II - 90088
Institucionální podpora: RVO:67985823 ; RVO:61388971 ; RVO:68378271
Klíčová slova: boron-doped diamond * chemical functionalization * enhanced surface area * nanocrystalline diamond * neural interface
Obor OECD: Neurosciences (including psychophysiology; Condensed matter physics (including formerly solid state physics, supercond.) (FZU-D); Biochemistry and molecular biology (MBU-M)
Impakt faktor: 1.481, rok: 2019
Způsob publikování: Omezený přístup
https://doi.org/10.1002/pssb.201800424

This article examines the ability of newly developed nanostructured porous boron-doped diamond (BDD) to form an interface with neural cells and the role of molecular functionalization by a polymer on this interface. Due to its high stability, biocompatibility, and electrical properties, BDD is a promising material for construction of neuroelectrodes. Nanostructuring and an increase in the surface specific area can further improve the sensitivity and performance of such electrodes. Here, porous BDD prepared in a multistep diamond deposition on a porous template consisting of a polymer and electrospun SiO2 fibers is examined. This work shows that this new material is biocompatible and does not exhibit any cytotoxicity on fibroblast cell lines. Further, this work shows that porous BDD supports regeneration of newborn and adult neurons when functionalized with poly-L-lysine.
Trvalý link: http://hdl.handle.net/11104/0296221