Flavonoid Glycosides from Endemic Bulgarian Astragalus aitosensis (Ivanisch.)

0504253 - ÚEB 2020 RIV CH eng J - Článek v odborném periodiku
Vasilev, H. - Ross, S. - Šmejkal, K. - Maršík, Petr - Jankovská, D. - Havlík, J. - Veselý, O.
Flavonoid Glycosides from Endemic Bulgarian Astragalus aitosensis (Ivanisch.).
Molecules. Roč. 24, č. 7 (2019), č. článku 1419. E-ISSN 1420-3049
Grant CEP: GA ČR(CZ) GA16-07193S; GA MŠMT(CZ) LD14079
Institucionální podpora: RVO:61389030
Klíčová slova: Astragalus aitosensis * flavonoid * glycoside
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 3.267, rok: 2019
Způsob publikování: Open access
http://doi.org/10.3390/molecules24071419

Astragalus is a very interesting plant genus, well-known for its content of flavonoids, triterpenes and polysaccharides. Its secondary metabolites are described as biologically active compounds showing several activities, e.g., immunomodulating, antibacterial, antiviral and hepatoprotective. This inspired us to analyze the Bulgarian endemic A. aitosensis (Ivanisch.) to obtain deeper information about its phenolic components. We used extensive chromatographic separation of A. aitosensis extract to obtain seven phenolic compounds (1-7), which were identified using combined LC-MS and NMR spectral studies. The 1D and 2D NMR analyses and HR-MS allowed us to resolve the structures of known compounds 5-7 as isorhamnetin-3-O-robinobioside, isorhamnetin-3-O-(2,6-di-O-alpha-rhamno-pyranosyl-beta-galactopyranoside), and alangiflavoside, respectively, and further comparison of these spectral data with available literature helped us with structural analysis of newly described flavonoid glycosides 1-4. These were described in plant source for the first time.
Trvalý link: http://hdl.handle.net/11104/0295925