Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1)

0504243 - FGÚ 2020 RIV NL eng J - Článek v odborném periodiku
Ježek, Petr - Jabůrek, Martin - Porter, R. K.
Uncoupling mechanism and redox regulation of mitochondrial uncoupling protein 1 (UCP1).
Biochimica Et Biophysica Acta-Bioenergetics. Roč. 1860, č. 3 (2019), s. 259-269. ISSN 0005-2728. E-ISSN 1879-2650
Grant CEP: GA ČR(CZ) GA17-01813S; GA MŠMT(CZ) LTAUSA17174
Institucionální podpora: RVO:67985823
Klíčová slova: mitochondrial uncoupling protein1 * UCP1 * fatty acid cycling * brown adipose tissue * redox regulation
Obor OECD: Physiology (including cytology)
Impakt faktor: 3.465, rok: 2019
Způsob publikování: Open access
https://doi.org/10.1016/j.bbabio.2018.11.007

Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondria] uncoupling protein 1 (UCP1), specific for these tissues, is the key factor for heat production. Recent molecular aspects of UCP1 structure provide support for the fatty acid cycling model of coupling, i.e. when UCP1 expels fatty acid anions in a uniport mode from the matrix, while uncoupling. Protonophoretic function is ensured by return of the protonated fatty acid to the matrix independent of UCP1. This mechanism is advantageous for mitochondrial uncoupling and compatible with heat production in a pro-thermogenic environment, such as BAT. It must still be verified whether post translational modification of UCP1, such as sulfenylation of Cys253, linked to redox activity, promotes UCP1 activity. BAT biogenesis and UCP1 expression, has also been linked to the pro-oxidant state of mitochondria, further endorsing a redox signalling link promoting an establishment of pro-thermogenic state. We discuss circumstances under which promotion of superoxide formation exceeds its attenuation by uncoupling in mitochondria and throughout point out areas of future research into UCP1 function.
Trvalý link: http://hdl.handle.net/11104/0295921