Metabolomics Study of the Association between Pancreatic Cancer and Diabetes Mellitus.

0503942 - ÚCHP 2020 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Michálková, Lenka - Horník, Štěpán - Sýkora, Jan - Habartová, L. - Setnička, V.
Metabolomics Study of the Association between Pancreatic Cancer and Diabetes Mellitus.
Book of Abstracts. Prague: Institute of Chemical Process Fundamentals of the CAS, v. v. i., 2019, s. 29, č. článku O9. ISBN 978-80-86186-97-9.
[Magnetic Moments in Central Europe 2019. Prague (CZ), 27.02.2019-03.03.2019]
Institucionální podpora: RVO:67985858
Klíčová slova: pancreatic cancer * nmr metabolomics * biomarker panel
Obor OECD: Medical laboratory technology (including laboratory samples analysis

In our study, 1H NMR metabolomics was employed to plasma samples of pancreatic cancer patients, individuals with long-term diabetes mellitus type 2 (lasting more than 5 years) and healthy controls. The NMR analyses were followed by establishing a statistical model based on principal component analysis and discriminant analysis. The aim was to discover differences between these groups and to define a potential biomarker panel. The statistical evaluation of metabolomics-based profiles provided high values of sensitivity and specificity. Subsequently, plasma samples of the risk group, specifically patients with recently diagnosed diabetes mellitus with a duration of <3 years (possible T3cDM), were analysed and the possibility of PC development was predicted. The achieved results showed strong potential of 1H NMR metabolomics to establish a biomarker panel that would facilitate the early diagnosis of PC and the possibility identify diabetic individuals, who are at risk of developing PC.
Trvalý link: http://hdl.handle.net/11104/0295701