T-Type Channel Druggability at a Crossroads

0503935 - ÚOCHB 2020 RIV US eng J - Článek v odborném periodiku
Weiss, Norbert - Zamponi, G. W.
T-Type Channel Druggability at a Crossroads.
ACS Chemical Neuroscience. Roč. 10, č. 3 (2019), s. 1124-1126. ISSN 1948-7193. E-ISSN 1948-7193
Institucionální podpora: RVO:61388963
Klíčová slova: calcium channels * T-type channels * Ca(v)3 channels * pharmacology * drug discovery * neuron * epilepsy * neuropathic pain
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 4.486, rok: 2019
Způsob publikování: Omezený přístup
https://pubs.acs.org/doi/10.1021/acschemneuro.9b00031

Low-voltage activated T-type calcium channels mediate essential functions in the nervous system, and alteration of channel activity is causally linked to a number of neurological conditions. Therefore, T-type channels hold great promise as pharmacological targets for new medicines. In this Viewpoint, we discuss the potential of T-type channels as druggable targets and reevaluate the strategies available for developing therapeutically efficient and specific modulators of this channel.
Trvalý link: http://hdl.handle.net/11104/0296772