NMR Metabolomics Study of the Association between Pancreatic Cancer and Diabetes Mellrtus.

0503928 - ÚCHP 2020 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Michálková, Lenka - Horník, Štěpán - Sýkora, Jan - Habartová, L. - Setnička, V.
NMR Metabolomics Study of the Association between Pancreatic Cancer and Diabetes Mellrtus.
Abstracts. Brno: Tribun EU, 2019 - (Novotný, J.; Marek, R.), č. článku C-19. ISBN 978-80-263-1462-2.
[34th NMR Valtice. Valtice (CZ), 31.03.2019-03.04.2019]
Institucionální podpora: RVO:67985858
Klíčová slova: pancreatic cancer * nmr analyses * biomarker panel
Obor OECD: Medical laboratory technology (including laboratory samples analysis

In our study, 1H NMR metabolomics was employed to plasma samples of pancreatic cancer patients, individuals with long-term diabetes mellitus type 2 (lasting more than 5 years) and healthy controls. The NMR analyses were followed by establishing a statistical model based on principal component analysis and discriminant analysis. The aim was to discover differences between these groups and to define a potential biomarker panel. The statistical evaluation of metabolomics-based profiles provided high values of sensitivity and specificity. Subsequently, plasma samples of the risk group, specifically patients with recently diagnosed diabetes mellitus with a duration of <3 years (possible T3cDM), were analysed and the possibility of PC development was predicted. The achieved results showed strong potential of 1H NMR metabolomics to establish a biomarker panel that would facilitate the early diagnosis of PC and the possibility identify diabetic individuals, who are at risk of developing PC.
Trvalý link: http://hdl.handle.net/11104/0295695