Method for Determination of Optical Purity of 2‐Arylpropanoic Acids Using Urea Derivatives Based on a 1,1′‐Binaphthalene Skeleton as Chiral NMR Solvating Agents: Advantages and Limitations Thereof.

0503744 - ÚCHP 2020 RIV US eng J - Článek v odborném periodiku
Cuřínová, Petra - Hájek, P. - Janků, K. - Holakovský, R.
Method for Determination of Optical Purity of 2‐Arylpropanoic Acids Using Urea Derivatives Based on a 1,1′‐Binaphthalene Skeleton as Chiral NMR Solvating Agents: Advantages and Limitations Thereof.
Chirality. Roč. 31, č. 5 (2019), s. 410-417. ISSN 0899-0042. E-ISSN 1520-636X
Grant CEP: GA ČR(CZ) GA17-00089S
Institucionální podpora: RVO:67985858
Klíčová slova: arylpropanoic acids * binaphthalene * chiral solvating agent
Obor OECD: Analytical chemistry
Impakt faktor: 2.171, rok: 2019
Způsob publikování: Omezený přístup

Five optically active urea derivatives (1‐5) were used as NMR solvating agents for analysis of the optical purity of different 2‐arylpropanoic acids commonly used as nonsteroidal anti‐inflammatory drugs. These novel chiral solvating agents were more efficient at discriminating the respective enantiomers of targets than the chiral solvating agents known so far, without the need to add a base for achieving the signal splitting. The advantages and limits of the use of these novel chiral solvating agents were studied.
Trvalý link: http://hdl.handle.net/11104/0298657