My Life with Developmental Cardiology

0503395 - FGÚ 2019 CA eng J - Článek v odborném periodiku
Ošťádal, Bohuslav
My Life with Developmental Cardiology.
CV Network. Roč. 17, č. 2 (2018), s. 2-7
Institucionální podpora: RVO:67985823
Klíčová slova: developmental cardiology * heart * cardiovascular system
Obor OECD: Cardiac and Cardiovascular systems

Developmental approach in medical sciences and particularly in cardiology offers new possibilities in the experimental studies of pathogeny, prevention and therapy of cardiovascular diseases. The structure and function of the developing heart are intrinsically linked, so studying both morphology and physiology provides added value and helps with data interpretation. The differences between individual stages of ontogenetic development are often more profound than differences between species, so translation of data obtained in animal studies to humans needs to be primarily considered in developmental terms (for example, newborn rodents are more similar to third trimester human fetuses than to neonates). Recent advances in our understanding of reactions of the immature heart could help in devising optimal protection strategies for the immature heart. Recent advances of new methodology, particularly molecular biology and genetics, may substantially help in the laborious search for a better understanding of the underlying mechanisms. Nevertheless, molecular analysis in developmental cardiology is unthinkable without comprehensive and well integrated view of the field.
Trvalý link: http://hdl.handle.net/11104/0295211