Synthesis of amphiphilic copolymers based on dendritic polyethylene grafted by polyhydroxyethylmethacrylate and polyhydroxypropylmethacrylate and their use for construction of nanoparticles

0503306 - ÚMCH 2020 RIV GB eng J - Článek v odborném periodiku
Nunvářová, K. - Charvátová, B. - Šlouf, Miroslav - Hermanová, S. - Merna, J.
Synthesis of amphiphilic copolymers based on dendritic polyethylene grafted by polyhydroxyethylmethacrylate and polyhydroxypropylmethacrylate and their use for construction of nanoparticles.
European Polymer Journal. Roč. 115, June (2019), s. 193-200. ISSN 0014-3057. E-ISSN 1873-1945
Institucionální podpora: RVO:61389013
Klíčová slova: amphiphilic copolymer nanoparticle * chain-walking polymerization * dendritic polyethylene
Obor OECD: Polymer science
Impakt faktor: 3.862, rok: 2019
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S0014305719300643?via%3Dihub

By grafting from approach amphiphilic grafted copolymers with a hydrophobic core based on dendritic polyethylene and hydrophilic grafts of polyhydroxyethylmethacrylate (PHEMA) and polyhydroxypropylmethacrylate (PHPMA) were synthesized by tandem chain walking copolymerization and ATRP. Copolymers with molar mass 160–1400 kg/mol and ∼50–90% of hydrophilic grafts were obtained. Core-shell nanoparticles with very narrow size distribution were prepared from the copolymers by solvent displacement method. Particles diameter was efficiently regulated by molar mass of the copolymers in the range of 60–180 nm. We demonstrated that these nanoparticles can act as nanocontainers for hydrophobic Nile red dye, achieving up to 25% encapsulation efficiency. Dendritic polyethylene (dPE) nanoparticles with biocompatible polar PHEMA and PHPMA shell can find application in nanocatalysis and cargo delivery.
Trvalý link: http://hdl.handle.net/11104/0295436