Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance

0503022 - ÚOCHB 2020 RIV US eng J - Článek v odborném periodiku
Enkavi, G. - Javanainen, Matti - Kulig, W. - Róg, T. - Vattulainen, I.
Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.
Chemical Reviews. Roč. 119, č. 9 (2019), s. 5607-5774. ISSN 0009-2665. E-ISSN 1520-6890
Institucionální podpora: RVO:61388963
Klíčová slova: molecular dynamics simulations * cellular functions * membrane complexity
Obor OECD: Biophysics
Impakt faktor: 52.760, rok: 2019
Způsob publikování: Open access
https://pubs.acs.org/doi/full/10.1021/acs.chemrev.8b00538

Biological membranes are tricky to investigate. They are complex in terms of molecular composition and structure, functional over a wide range of time scales, and characterized by nonequilibrium conditions. Because of all of these features, simulations are a great technique to study biomembrane behavior. A significant part of the functional processes in biological membranes takes place at the molecular level, thus computer simulations are the method of choice to explore how their properties emerge from specific molecular features and how the interplay among the numerous molecules gives rise to function over spatial and time scales larger than the molecular ones. In this review, we focus on this broad theme. We discuss the current state-of-the-art of biomembrane simulations that, until now, have largely focused on a rather narrow picture of the complexity of the membranes. Given this, we also discuss the challenges that we should unravel in the foreseeable future. Numerous features such as the actin-cytoskeleton network, the glycocalyx network, and nonequilibrium transport under ATP-driven conditions have so far received very little attention, however, the potential of simulations to solve them would be exceptionally high. A major milestone for this research would be that one day we could say that computer simulations genuinely research biological membranes, not just lipid bilayers.
Trvalý link: http://hdl.handle.net/11104/0296595