Ectoparasites: Drug Discovery Against Moving Targets

0503008 - BC 2019 RIV DE eng M - Část monografie knihy
Kopáček, Petr - Perner, Jan - Sojka, Daniel - Šíma, Radek - Hajdušek, Ondřej
Molecular Targets to Impair Blood Meal Processing in Ticks.
Ectoparasites: Drug Discovery Against Moving Targets. Wenheim: Wiley‐VCH Verlag GmbH & Co. KGaA., 2018 - (Meng, C.; Sluder, A.), s. 139-165. ISBN 9783527341689
Grant CEP: GA ČR GA13-11043S; GA ČR GA14-33693S; GA ČR(CZ) GA17-27386S; GA ČR(CZ) GA17-27393S; GA ČR(CZ) GA18-01832S
Institucionální podpora: RVO:60077344
Klíčová slova: molecular * process * blood * ticks * biosynthesis
Obor OECD: Microbiology

Feeding and digestion of host blood are key physiological processes providing essential nutrients for the development and fecundity of ticks. Ingested host blood, which exceeds the weight of unfed females by more than one hundred times, is concentrated and stored in the tick gut lumen, gradually being taken up by digestive cells, and intracellularly digested by a multi‐enzyme network of acidic aspartic and cysteine endo‐ and exo‐peptidases. Digestion of hemoglobin, the major protein component of blood, results in the release of a vast excess of potentially toxic heme. In most eukaryotic cells, heme and iron homeostasis is based on a balanced flux between heme biosynthesis and heme degradation, mediated by heme oxygenase. In contrast, ticks are not capable of synthesizing or degrading heme. Therefore, ticks have evolved specific molecular mechanisms of heme and iron acquisition, detoxification, intracellular trafficking, and inter‐tissue transport. This chapter reviews current knowledge on the molecular mechanisms of these processes and discusses their potential as targets for antitick interventions.
Trvalý link: http://hdl.handle.net/11104/0294843