Advances in Chemical Biology

0502875 - ÚMG 2019 RIV CZ eng M - Část monografie knihy
Epp, Trevor - Schuster, Bjorn - Chawengsaksophak, Kallayanee
LINE-1 repression in human cancer.
Advances in Chemical Biology. Praha: OPTIO CZ, 2019 - (Bartůněk, P.), s. 64-75. ISBN 978-80-88011-03-3
Grant CEP: GA MŠMT LO1220
Institucionální podpora: RVO:68378050
Klíčová slova: LINE-1 retrotransposon * FAM208A * human silencing hub
Obor OECD: Cell biology

The LINE-1 retrotransposon comprises 17% of the human genome, although only a few intact copies currently remain “hot”, capable of retrotransposition. LINE-1 elements have long been used as a cancer biomarker and, more recently, their expression has been associated with residual cancer stem cells resistant to chemotherapy. This poses a challenge as LINE-1 derepression can result in further cancer-driving mutations, both through somatic retrotransposition or through inter-LINE-1 recombination. FAM208A and other members of the HUSH (human silencing hub) complex have recently emerged as novel restriction factors for LINE-1 transposable elements. We will discuss these findings in context with previously known functions of the HUSH complex and discuss the prospectivity of targeting this complex for cancer treatment.
Trvalý link: http://hdl.handle.net/11104/0294998