Fluorine polymer probes for magnetic resonance imaging: quo vadis?

0502602 - ÚMCH 2020 RIV DE eng J - Článek v odborném periodiku
Jirák, D. - Galisová, A. - Kolouchová, Kristýna - Babuka, David - Hrubý, Martin
Fluorine polymer probes for magnetic resonance imaging: quo vadis?
Magnetic Resonance Materials in Physics, Biology and Medicine. Roč. 32, č. 1 (2019), s. 173-185. ISSN 0968-5243. E-ISSN 1352-8661
Grant CEP: GA ČR(CZ) GA16-03156S; GA ČR(CZ) GA18-07983S
Institucionální podpora: RVO:61389013
Klíčová slova: fluorine * magnetic resonance imaging (MRI) * polymer
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 1.956, rok: 2019
Způsob publikování: Open access
https://link.springer.com/content/pdf/10.1007/s10334-018-0724-6.pdf

Over the last few years, the development and relevance of 19F magnetic resonance imaging (MRI) for use in clinical practice has emerged. MRI using fluorinated probes enables the achievement of a specific signal with high contrast in MRI images. However, to ensure sufficient sensitivity of 19F MRI, fluorine probes with a high content of chemically equivalent fluorine atoms are required. The majority of 19F MRI agents are perfluorocarbon emulsions, which have a broad range of applications in molecular imaging, although the content of fluorine atoms in these molecules is limited. In this review, we focus mainly on polymer probes that allow higher fluorine content and represent versatile platforms with properties tailorable to a plethora of biomedical in vivo applications. We discuss the chemical development, up to the first imaging applications, of these promising fluorine probes, including injectable polymers that form depots that are intended for possible use in cancer therapy.
Trvalý link: http://hdl.handle.net/11104/0295135