Detection of Distinct Changes in Gene-expression Profiles in Specimens of Tumors and Transition Zones of Tenascin-positive/-negative Head and Neck Squamous Cell Carcinoma

0502489 - ÚMG 2019 RIV GR eng J - Článek v odborném periodiku
Živicová, V. - Gal, P. - Mifkova, A. - Novák, S. - Kaltner, H. - Kolář, Michal - Strnad, Hynek - Šáchová, Jana - Hradilová, Miluše - Chovanec, M. - Gabius, H. J. - Smetana, K. - Fík, Z.
Detection of Distinct Changes in Gene-expression Profiles in Specimens of Tumors and Transition Zones of Tenascin-positive/-negative Head and Neck Squamous Cell Carcinoma.
Anticancer Research. Roč. 38, č. 3 (2018), s. 1279-1290. ISSN 0250-7005. E-ISSN 1791-7530
Grant CEP: GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:68378050
Klíčová slova: Extracellular matrix * fibronectin * galectin * tenascin * tumor * stroma
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 1.935, rok: 2018

Background/Aim: Having previously initiated genome-wide expression profiling in head and neck squamous cell carcinoma (HNSCC) for regions of the tumor, the margin of surgical resecate (MSR) and normal mucosa (NM), we here proceed with respective analysis of cases after stratification according to the expression status of tenascin (Ten). Materials and Methods: Tissue specimens of each anatomical site were analyzed by immunofluorescent detection of Ten, fibronectin (Fn) and galectin-1 (Gal-1) as well as by microarrays.
Trvalý link: http://hdl.handle.net/11104/0294418