Human Neural Stem Cells

0502087 - ÚEM 2019 RIV DE eng M - Část monografie knihy
Jendelová, Pavla - Syková, E. - Erceg, S.
Neural Stem Cells Derived from Human-Induced Pluripotent Stem Cells and Their Use in Models of CNS Injury.
Human Neural Stem Cells. Cham: Springer, 2018 - (Buzanska, L.), s. 89-102. Results and Problems in Cell Differentiation, 66. ISBN 978-3-319-93484-6
Grant CEP: GA MŠMT(CZ) LO1309; GA MŠMT(CZ) EF15_003/0000419; GA ČR(CZ) GBP304/12/G069
Institucionální podpora: RVO:68378041
Klíčová slova: induced pluripotent stem cells * neural stem cells * neuronal differentiation * stroke
Obor OECD: Neurosciences (including psychophysiology

Induced pluripotent stem - iPS cells are derived from differentiated cells by different reprogramming techniques, by introducing specific transcription factors responsible for pluripotency. Induced pluripotent stem cells can serve as an excellent source for differentiated neural stem/progenitor cells - NSCs/NPs. Several methods and protocols are utilized to create a robust number of NSCs/NPs without jeopardizing the safety issues required for in vivo applications. A variety of disease-specific iPS cells have been used to study nervous system diseases. In this chapter, we will focus on some of the derivation and differentiation approaches and the application of iPS-NPs in the treatment of spinal cord injury and stroke.
Trvalý link: http://hdl.handle.net/11104/0294067