Heat Shock Proteins in Veterinary Medicine and Sciences

0502020 - BC 2020 RIV DE eng M - Část monografie knihy
Espinosa, P. J. - Alberdi, P. - Villar, M. - Cabezas Cruz, Alejandro - de la Fuente, J.
Heat Shock Proteins in Vector-pathogen Interactions: The Anaplasma phagocytophilum Model.
Heat Shock Proteins. In: Heat Shock Proteins in Veterinary Medicine and Sciences. Cham: Springer International Publishing, 2017 - (Asea, A.; Kaur, P.), Roč. 12 /2017/, s. 375-398. ISBN 978-3-319-73376-0
Institucionální podpora: RVO:60077344
Klíčová slova: aedes-albopictus cells * ixodes-scapularis * ornithodoros-moubata * gene-expression * drosophila-melanogaster * inhibits apoptosis * diptera-culicidae * immune-responses * stress responses * salivary-glands * Anaplasma phagocytophilum * Apoptosis * Heat shock proteins * Ixodes,s'capularis * Tick-borne diseases * Vaccine * Vector-pathogen interaction
Obor OECD: Genetics and heredity (medical genetics to be 3)

Anaplasma phogocytophihun is an emerging zoonotic pathogen that is transmitted by Ixodes ticks and causes human granulocytic anaplasmosis. Several recent studies have shown that tick infection by A. phagocytophilum induces complex changes mediated by different, mechanisms such as remodeling of cytoskeleton, inhibition of cell apoptosis, modification of metabolism and cell epigenetics, manipulation of the immune response and stress response. In particular, heat shock proteins (lisp), a group of highly conserved proteins, play an important role in tick pathogen interactions. Not only tick ftsp mediate the response to A. phagocytophibun infection, but also bacterial lisp bind tick and vertebrate host cells. Herein, we reviewed the literature and provided new insides on the role of bacterial and tick lisp in tick-pathogen interactions. We combined the analysis of published data on genomics, transcriptomics and proteomics of the response of Ixodes scapularis ticks to A. phagocytophilum infection. In addition, functional. studies were conducted to test some of the hypotheses on the role of tick Hsp in response to A. phagocytophilum infection. These results provide a more comprehensive view of the major Hsp involved in the response to pathogen infection in ticks.
Trvalý link: http://hdl.handle.net/11104/0293975