Obesity, First-episode Psychosis and Lower Brain Gray Matter Volumes

0502003 - ÚI 2020 NL eng A - Abstrakt
Kolenic, M. - Hlinka, Jaroslav - Španiel, F. - Hájek, T.
Obesity, First-episode Psychosis and Lower Brain Gray Matter Volumes.
European Neuropsychopharmacology. Elsevier. Roč. 29, Suppl. 2 (2019), S708-S708, č. článku P.4.10. ISSN 0924-977X. E-ISSN 1873-7862.
[ECNP 2019. Workshop for Early Career Scientists in Europe. 07.03.2019-10.03.2019, Nice]
Grant ostatní: GA MZd(CZ) NV16-32791A
Institucionální podpora: RVO:67985807
Klíčová slova: neuroimaging * magnetic resonance imaging * schizophrenia * voxel based morphometry * obesity * body-mass index
Obor OECD: Neurosciences (including psychophysiology

Gray matter (GM) reductions are often reported in schizophrenia, but their origins remain unknown. One potential source of neuroimaging abnormalities in psychotic disorders is the comorbidity with medical conditions known to affect the brain. Almost 20% of participants with first-episode psychosis (FEP) are obese. Obesity is frequently associated with antipsychotic treatment as well as neurostructural alterations. We previously reported that both the diagnosis of FEP and obesity/overweight were additively associated with advanced brain age. Importantly, BMI increased significantly during hospitalization of participants with FEP, probably as effect of antipsychotic mediaction. Here, Based on our previous study we tested the hypothesis that both FEP and BMI are negatively associated with GM volumes. It is unclear to what extent weight gain related to antipsychotics contributes to these alterations.
Trvalý link: http://hdl.handle.net/11104/0293963