Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition

0501686 - BFÚ 2019 RIV GB eng J - Článek v odborném periodiku
Remšík, Jan - Binó, Lucia - Kahounová, Zuzana - Kharaishvili, G. - Šimečková, Šárka - Fedr, Radek - Kučírková, T. - Lenart, S. - Muresan, Ximena Maria - Slabáková, Eva - Knopfová, L. - Bouchal, J. - Král, M. - Beneš, P. - Souček, Karel
Trop-2 plasticity is controlled by epithelial-to-mesenchymal transition.
Carcinogenesis. Roč. 39, č. 11 (2018), s. 1411-1418. ISSN 0143-3334. E-ISSN 1460-2180
Grant CEP: GA MZd(CZ) NV15-33999A; GA MZd(CZ) NV15-28628A
Institucionální podpora: RVO:68081707
Klíčová slova: cancer metastasis * prostate-cancer * cells * expression
Obor OECD: Cell biology
Impakt faktor: 4.004, rok: 2018

The cell surface glycoprotein Trop-2 is commonly overexpressed in carcinomas and represents an exceptional antigen for targeted therapy. Here, we provide evidence that surface Trop-2 expression is functionally connected with an epithelial phenotype in breast and prostate cell lines and in patient tumor samples. We further show that Trop-2 expression is suppressed epigenetically or through the action of epithelial-to-mesenchymal transition transcription factors and that deregulation of Trop-2 expression is linked with cancer progression and poor patient prognosis. Moreover, our data suggest that the cancer plasticity-driven intratumoral heterogeneity in Trop-2 expression may significantly contribute to response and resistance to therapies targeting Trop-2-expressing cells.
Trvalý link: http://hdl.handle.net/11104/0293681