First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

0501235 - FZÚ 2019 RIV GB eng J - Článek v odborném periodiku
Cirrone, G. A. P. - Manti, L. - Margarone, Daniele - Petringa, G. - Giuffrida, Lorenzo - Minopoli, A. - Picciotto, A. - Russo, G. - Cammarata, F. - Pisciotta, P. - Perozziello, F.M. - Romano, F. - Marchese, V. - Milluzzo, G. - Scuderi, Valentina - Cuttone, G. - Korn, Georg
First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness.
Scientific Reports. Roč. 8, Jan (2018), s. 1-15, č. článku 1141. ISSN 2045-2322. E-ISSN 2045-2322
Grant CEP: GA MŠMT EF15_003/0000447; GA MŠMT LQ1606
Grant ostatní: OP VVV - ELIBIO(XE) CZ.02.1.01/0.0/0.0/15_003/0000447
Institucionální podpora: RVO:68378271
Klíčová slova: relative biological effectiveness * carbon-ion-beams * chromosome-aberrations * neutron-capture * human-lymphocytes * alpha-particles * radiation-therapy
Obor OECD: Fluids and plasma physics (including surface physics)
Impakt faktor: 4.011, rok: 2018

Protontherapy is hadrontherapy's fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy's superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET ( Linear Energy Transfer) C-12-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper C-12-ion clinical amenability. Thus, enhancing proton RBE is desirable. To this end, we exploited the p + B-11 -> 3 alpha reaction to generate high-LET alpha particles with a clinical proton beam.Boron-Neutron Capture Therapy (BNCT) uses B-10-enriched BSH for neutron irradiationtriggered alpha particles. We recorded significantly increased cellular lethality and chromosome aberration complexity.
Trvalý link: http://hdl.handle.net/11104/0293229