Antimicrobial peptides and their use for the treatment of topical infections

0501083 - ÚOCHB 2019 RIV eng P - Patentový dokument
Čeřovský, Václav - Nešuta, Ondřej - Dudková, Vlasta - Sychrová, Hana - Kodedová, Marie
Antimicrobial peptides and their use for the treatment of topical infections.
2018. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. - Fyziologický ústav AV ČR, v. v. i. Datum udělení patentu: 25.12.2018. Číslo patentu: US10160785
Grant CEP: GA TA ČR(CZ) TA04010638
Institucionální podpora: RVO:61388963 ; RVO:67985823
Klíčová slova: antimicrobial peptides * topical infections * microbial biofilm
Obor OECD: Microbiology
https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20181225&DB=EPODOC&locale=&CC=US&NR=10160785B2&KC=B2&ND=4#

Synthetic analogs of general formula (I-A), 5 a-Ile-b-c-d-e-f-Lys-Lys-g-h-i-j-Ile-k-Lys-NH2 (I-A) where a is Gly, Lys or β-Ala, b is Met, Leu, Nle, Ile, Trp, Val or Phe, c is Ser, Lys, Arg or Orn, d is Ser, Lys, Arg or Orn, e is Leu, Nle, Ile, Trp, Val or Phe, f is Met, Leu, Nle, Ile, Trp, Val or Phe, g is Leu, Nle, Ile orTrp, h is Lys, Arg, Orn or Ala, i is Lys, Arg, Orn or Ala, j is Ile, Leu, Nle or His, k is Lys, Arg, Orn or Ala, where amino acids in all positions may be in D-configuration, and their use for the treatment of topical infections caused by pathogenic bacteria or yeasts.
Trvalý link: http://hdl.handle.net/11104/0293140