Improving kinetic inertness of MRI probes to prevent gadolinium release

0500681 - ÚOCHB 2019 US eng A - Abstrakt
Polášek, Miloslav - Kretschmer, Jan - David, Tomáš
Improving kinetic inertness of MRI probes to prevent gadolinium release.
WMIC 2018. World Molecular Imaging Congress. Seattle: WMIS, 2018. "LBAP 100".
[WMIC 2018. World Molecular Imaging Congress. 12.09.2018-15.09.2018, Seattle]
Institucionální podpora: RVO:61388963
Klíčová slova: gadolinium * MRI contrast agents * gadolinium retention
Obor OECD: Inorganic and nuclear chemistry

Gadolinium-based MRI contrast agents release and deposit gadolinium in patients. Little is known about the relationship between structure of macrocyclic contrast agents and their ability to release gadolinium. This work shows that decreasing basicity of macrocycle nitrogen atoms and use of non-protonizable coordinating arms help prevent gadolinium release from the macrocyclic agents. These are promising ways for construction of safer gadolinium-based contrast agents.
Trvalý link: http://hdl.handle.net/11104/0292744