Nanostructures in Biomedicine: Their Regenerative and toxic properties

0500149 - ÚEM 2019 RIV CZ eng M - Část monografie knihy
Růžička, Jiří - Jendelová, Pavla
Hibernation, Brain Cooling and Neuronal Plasticity.
Nanostructures in Biomedicine: Their Regenerative and toxic properties. Praha 3: Proxima Tisk, s.r.o., 2018 - (Pamula, E.), s. 194-198. ISBN 978-80-906655-7-6
Grant CEP: GA MŠMT(CZ) LO1309
Institucionální podpora: RVO:68378041
Klíčová slova: Hibernation * adenosine * synapses retraction
Obor OECD: Neurosciences (including psychophysiology

Hibernation has long been of interest in many scientific fields including tissue regeneration and neuroscience. Such a drastic saving in energy expenditure results in very plastic mechanisms and must include protective mechanisms at both the cellular and organ level. This chapter focuses on the regulatory mechanisms of hibernation and the torpor state, by introducing several simplified examples such as hypoxia, hypothermia, gaseous mediators and adenosine induced hibernation like states, which partially show the complexity of such behaviour, and identifies some of the brain regions which might be responsible for the induction and regulation of torpor. Moreover, the chapter shows some of the roles of the microtubule associated protein Tau, and its role in hibernation and parallels to neurodegenerative diseases, along with some of the reparative and neuroprotective mechanisms which allow such behaviour to overcome the entropy which comes with energy savings
Trvalý link: http://hdl.handle.net/11104/0293714