Nanostructures in Biomedicine: Their Regenerative and toxic properties

0500147 - ÚEM 2019 RIV CZ eng M - Část monografie knihy
Kárová, Kristýna - Jendelová, Pavla
Autophagy and Its Role in Spinal Cord Injury.
Nanostructures in Biomedicine: Their Regenerative and toxic properties. Praha 3: Proxima Tisk, s.r.o., 2018 - (Pamula, E.), s. 188-193. ISBN 978-80-906655-7-6
Grant CEP: GA MŠMT(CZ) LO1309
Institucionální podpora: RVO:68378041
Klíčová slova: autophagy * mTOR * spinal cord injury
Obor OECD: Neurosciences (including psychophysiology

Autophagy is a widely studied process involved in maintaining cellular homeostasis, clearance and degradation of faulty or excess proteins and organelles and ultimately in refreshing the intracellular space. It is highly regulated and constitutively present in cells across species. Defects in autophagy have been associated with a number of pathologies, such as cancer or neurodegenerative diseases often linked with accumulation of misfolded or aggregated proteins. It has been shown to be active after trauma to the spinal cord and may be the key target for spinal cord injury (SCI) therapy. In this review, the process of autophagy is described and crucial phases in the development of functional autolysosome are highlighted, both under conditions of nutritional deficits or after SCI along with therapies aiming to enhance it.

Trvalý link: http://hdl.handle.net/11104/0293605