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The relationship between structure and in vitro antistaphylococcal effect of plant-derived stilbenes
- 1.0499672 - ÚEB 2019 RIV HU eng J - Článek v odborném periodiku
Žáková, T. - Rondevaldová, J. - Bernardos, A. - Landa, Přemysl - Kokoška, L.
The relationship between structure and in vitro antistaphylococcal effect of plant-derived stilbenes.
Acta Microbiologica et Immunologica Hungarica. Roč. 65, č. 4 (2018), s. 467-476. ISSN 1217-8950. E-ISSN 1588-2640
Grant CEP: GA ČR(CZ) GA16-07193S
Institucionální podpora: RVO:61389030
Klíčová slova: Antimicrobial activity * Minimum inhibitory concentration * Natural antibacterial agents * Staphylococcus aureus * Structure-activity relationships
Obor OECD: Microbiology
Impakt faktor: 1.079, rok: 2018
Staphylococcus aureus is a major human pathogen that is responsible for both hospital- and community-acquired infections. Stilbenes are polyphenol compounds of plant origin known to possess a variety of pharmacological properties, such as antibacterial, antiviral, and antifungal effects. This study reports the in vitro growth-inhibitory potential of eight naturally occurring stilbenes against six standard strains and two clinical isolates of S. aureus, using a broth microdilution method, and expressing the results as minimum inhibitory concentrations (MICs). Pterostilbene (MICs = 32-128 μg/ml), piceatannol (MICs = 64-256 μg/ml), and pinostilbene (MICs = 128 μg/ml) are among the active compounds that possess the strongest activity against all microorganisms tested, followed by 3′-hydroxypterostilbene, isorhapontigenin, oxyresveratrol, and rhapontigenin with MICs 128-256 μg/ml. Resveratrol (MIC = 256 μg/ml) exhibited only weak inhibitory effect. Furthermore, structure-activity relationships were studied. Hydroxyl groups at ortho-position (B-3′ and4′) played crucial roles for the inhibitory effect of hydroxystilbene piceatannol. Compounds with methoxy groups at ring A (3′-hydroxypterostilbene, pinostilbene, and pterostilbene) produced stronger effect against S. aureus than their analogues (isorhapontigenin and rhapontigenin) with methoxy groups at ring B. These findings provide arguments for further investigation of stilbenes as prospective leading structures for development of novel antistaphylococcal agents for topical treatment of skin infections.
Trvalý link: http://hdl.handle.net/11104/0291899
Název souboru Staženo Velikost Komentář Verze Přístup 2018_Zakova_ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA_467.pdf 1 247.2 KB Jiná povolen
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