Nanostructures in Biomedicine: Their Regenerative and toxic properties

0499416 - ÚEM 2019 RIV CZ eng M - Část monografie knihy
Novotná, Božena - Sikorová, Jitka - Milcová, Alena - Rössner ml., Pavel - Brzicová, Táňa - Topinka, Jan
The Assessmebt of Genotoxic Potential of Organic Extracts from Particulate Truck Emissions from Diesel or Biodiesel (B100) Fuel.
Nanostructures in Biomedicine: Their Regenerative and toxic properties. Praha 3: Proxima Tisk, s.r.o., 2018 - (Pamula, E.), s. 48-54. ISBN 978-80-906655-7-6
Grant CEP: GA MŠMT(CZ) LO1508
Institucionální podpora: RVO:68378041
Klíčová slova: A549 cells * biodiesel * Comet assay
Obor OECD: Cell biology

In A549 cells, the emissions from diesel induced a stronger genotoxic effect than those from biodiesel. The emissions from extended engine idling appeared to be the most genotoxic. Oxidized DNA was repaired within 24 hours independently of fuel and engine operating mode. This suggests that various compounds play a key role in the genotoxicity of diesel and biodiesel.
Trvalý link: http://hdl.handle.net/11104/0293445