Počet záznamů: 1
A bite so sweet: the glycobiology interface of tick-host-pathogen interactions
- 1.0498840 - BC 2019 RIV GB eng J - Článek v odborném periodiku
Věchtová, Pavlína - Štěrbová, Jarmila - Štěrba, Ján - Vancová, Marie - Rego, Ryan O. M. - Selinger, Martin - Strnad, Martin - Golovchenko, Maryna - Rudenko, Natalia - Grubhoffer, Libor
A bite so sweet: the glycobiology interface of tick-host-pathogen interactions.
Parasites & Vectors. Roč. 11, č. 1 (2018), č. článku 594. ISSN 1756-3305. E-ISSN 1756-3305
Grant CEP: GA MŠMT(CZ) EE2.3.30.0032; GA MŠMT(CZ) LM2015062; GA ČR(CZ) GA15-03044S; GA MŠMT(CZ) LTARF18021
GRANT EU: European Commission(XE) 602272 - ANTIDotE; European Commission(XE) 278976 - ANTIGONE
Institucionální podpora: RVO:60077344
Klíčová slova: Borrelia * Anaplasma * Glycan * Glycobiology * Host * Lectin * Pathogen * tbev * Tick * Carbohydrate-binding
Obor OECD: Microbiology
Impakt faktor: 3.031, rok: 2018
Způsob publikování: Open access
https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-018-3062-7
Vector-borne diseases constitute 17% of all infectious diseases in the world, among the blood-feeding arthropods, ticks transmit the highest number of pathogens. Understanding the interactions between the tick vector, the mammalian host and the pathogens circulating between them is the basis for the successful development of vaccines against ticks or the tick-transmitted pathogens as well as for the development of specific treatments against tick-borne infections. A lot of effort has been put into transcriptomic and proteomic analyses, however, the protein-carbohydrate interactions and the overall glycobiology of ticks and tick-borne pathogens has not been given the importance or priority deserved. Novel (bio)analytical techniques and their availability have immensely increased the possibilities in glycobiology research and thus novel information in the glycobiology of ticks and tick-borne pathogens is being generated at a faster pace each year. This review brings a comprehensive summary of the knowledge on both the glycosylated proteins and the glycan-binding proteins of the ticks as well as the tick-transmitted pathogens, with emphasis on the interactions allowing the infection of both the ticks and the hosts by various bacteria and tick-borne encephalitis virus.
Trvalý link: http://hdl.handle.net/11104/0291110
Počet záznamů: 1