Počet záznamů: 1  

Fe–S cluster assembly in the supergroup Excavata

  1. 1.
    0498794 - BC 2019 RIV DE eng J - Článek v odborném periodiku
    Peña-Diaz, Priscila - Lukeš, Julius
    Fe–S cluster assembly in the supergroup Excavata.
    Journal of Biological Inorganic Chemistry. Roč. 23, č. 4 (2018), s. 521-541. ISSN 0949-8257. E-ISSN 1432-1327
    Grant CEP: GA ČR(CZ) GA16-18699S; GA MŠMT LL1601; GA MŠMT(CZ) EF16_019/0000759
    Grant ostatní: COST (European Cooperation in Science and Technology)(BE) COST Action CA15133
    Program: The Biogenesis of Iron-sulfur Proteins: from Cellular Biology to Molecular Aspects (FeSBioNet)
    Institucionální podpora: RVO:60077344
    Klíčová slova: Evolution * Excavata * Fe–S cluster * Mitochondria
    Obor OECD: Genetics and heredity (medical genetics to be 3)
    Impakt faktor: 3.632, rok: 2018
    Způsob publikování: Open access

    The majority of established model organisms belong to the supergroup Opisthokonta, which includes yeasts and animals. While enlightening, this focus has neglected protists, organisms that represent the bulk of eukaryotic diversity and are often regarded as primitive eukaryotes. One of these is the “supergroup” Excavata, which comprises unicellular flagellates of diverse lifestyles and contains species of medical importance, such as Trichomonas, Giardia, Naegleria, Trypanosoma and Leishmania. Excavata exhibits a continuum in mitochondrial forms, ranging from classical aerobic, cristae-bearing mitochondria to mitochondria-related organelles, such as hydrogenosomes and mitosomes, to the extreme case of a complete absence of the organelle. All forms of mitochondria house a machinery for the assembly of Fe–S clusters, ancient cofactors required in various biochemical activities needed to sustain every extant cell. In this review, we survey what is known about the Fe–S cluster assembly in the supergroup Excavata. We aim to bring attention to the diversity found in this group, reflected in gene losses and gains that have shaped the Fe–S cluster biogenesis pathways.
    Trvalý link: http://hdl.handle.net/11104/0291070

     
     
Počet záznamů: 1  

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