Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients

0498773 - ÚI 2019 GB eng J - Článek v odborném periodiku
Truxová, I. - Kašíková, L. - Hensler, M. - Skapa, P. - Laco, J. - Pecen, Ladislav - Belicová, L. - Práznovec, I. - Halaška, M. - Brtnický, T. - Šálková, E. - Rob, L. - Kodet, R. - Goc, J. - Sautes-Fridman, C. - Fridman, W. H. - Ryška, A. - Galluzzi, L. - Špíšek, R. - Fučíková, J.
Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients.
Journal for ImmunoTherapy of Cancer. Roč. 6, 4 December (2018), č. článku 139. E-ISSN 2051-1426
Klíčová slova: CD8+ cytotoxic T lymphocytes * DC-LAMP * Dendritic cells * Natural killer cells * Tertiary lymphoid structures
Impakt faktor: 8.728, rok: 2018

A high density of tumor-infiltrating CD8+ T cells and CD20+ B cells correlates with prolonged survival in patients with a wide variety of human cancers, including high-grade serous ovarian carcinoma (HGSC). However, the potential impact of mature dendritic cells (DCs) in shaping the immune contexture of HGSC, their role in the establishment of T cell-dependent antitumor immunity, and their potential prognostic value for HGSC patients remain unclear. We harnessed immunohistochemical tests and biomolecular analyses to demonstrate that a high density of tumor-infiltrating DC-LAMP+ DCs is robustly associated with an immune contexture characterized by TH1 polarization and cytotoxic activity. We showed that both mature DCs and CD20+ B cells play a critical role in the generation of a clinically-favorable cytotoxic immune response in HGSC microenvironment. In line with this notion, robust tumor infiltration by both DC-LAMP+ DCs and CD20+ B cells was associated with most favorable overall survival in two independent cohorts of chemotherapy-naïve HGSC patients. Our findings suggest that the presence of mature, DC-LAMP+ DCs in the tumor microenvironment may represent a novel, powerful prognostic biomarker for HGSC patients that reflects the activation of clinically-relevant anticancer immunity.
Trvalý link: http://hdl.handle.net/11104/0291042