Studies in natural products chemsitry

0497889 - MBÚ 2019 RIV GB eng M - Část monografie knihy
Řezanka, Tomáš - Palyzová, Andrea - Faltýsková, Helena - Sigler, Karel
Siderophores: Amazing Metabolites of Microorganisms.
Studies in natural products chemsitry. Vol. 59. Oxford: Elsevier, 2018 - (Ur-Rahman, A.), s. 157-188. ISBN 978-0-444-64179-3
Grant CEP: GA MŠMT(CZ) LO1509
Institucionální podpora: RVO:61388971
Klíčová slova: siderophores * oxidation–reduction reactions * siderophore-mediated iron
Obor OECD: Microbiology

Iron is a transition metal that is naturally present in two valences (namely,Fe2+ and Fe3+) that form Fe(II) (ferrous) and Fe(III) (ferric) compounds.Due to its variable valences, iron plays a key role in oxidation–reduction reactions. At physiological pH (-7), Fe2+ is soluble while Fe3+ is almost insoluble. The concentration of dissolved ferrous iron is around 10 -10 to 10_9M, about two to three orders of magnitude less than the concentration required by living organisms (10 -7–10-5M). The maximum amount of uncomplexed ferric ion in solution at biological pH is probably not greater than 10_18M [1]. These environmental restrictions and biological requirements
have resulted in the evolution of a siderophore-mediated iron uptake system by some microorganisms. Microorganisms growing under aerobic conditions need iron for a variety of functions including reduction of oxygen for the synthesis of ATP, reduction of ribonucleotide precursors of DNA, formation of heme, and other essential purposes. A micromolar level of iron is needed for optimum growth.

Trvalý link: http://hdl.handle.net/11104/0290359