Diagnosis of Pancreatic Cancer via 1H NMR Metabolomics of Human Plasma.

0497576 - ÚCHP 2019 RIV GB eng J - Článek v odborném periodiku
Michálková, Lenka - Horník, Štěpán - Sýkora, Jan - Habartová, L. - Setnička, V.
Diagnosis of Pancreatic Cancer via 1H NMR Metabolomics of Human Plasma.
Analyst. Roč. 143, č. 24 (2018), s. 5974-5978. ISSN 0003-2654. E-ISSN 1364-5528
Institucionální podpora: RVO:67985858
Klíčová slova: NMR metabolomics * pancreatic cancer
Obor OECD: Analytical chemistry
Impakt faktor: 4.019, rok: 2018

Metabolic changes induced by pancreatic cancer were investigated by 1H NMR spectroscopy of plasma samples of patients and healthy controls. The acquired data were submitted to multivariate statistical analysis providing clear discrimination between both groups. The most significant differences were found in levels of 3-hydroxybutyrate and lactate. The obtained results (100% sensitivity, 90% specificity) clearly show the potential of 1H NMR spectroscopy in pancreatic cancer diagnosis. Therefore, the NMR-based metabolomics may contribute to the early diagnosis, prevention and/or therapy of diseases in the future. On the other hand, the number of samples in the presented pilot study is limited and has to be significantly increased in the future in order to obtain solid statistical models and to confirm the current findings.
Trvalý link: http://hdl.handle.net/11104/0291040