0496998 - ÚCHP 2019 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Kos, Martin - Váňa, Lubomír - Žádný, Jaroslav - Storch, Jan
Synthesis of Steroid Derivatives for In Vitro Diagnostics.
Book of Abstracts. Louvain-la-Neuve: Université catholique de Louvain, 2018 - (Gaigneux, E.), s. 6, č. článku P 32. ISBN N.
[Advances in Organic, Bioorganic and Pharmaceutical Chemistry LIBLICE 2018 /53./. Lázně Bělohrad (CZ), 02.11.2018-04.11.2018]
Grant CEP: GA MPO(CZ) FV20061
Institucionální podpora: RVO:67985858
Klíčová slova: steriod * dyagnostics * sythesis
Obor OECD: Organic chemistry

This work is focused on the synthesis of novel steroidal androgen derivatives consisting of a steroidal skeleton, a spacer and imidazole ring or a primary amine functional group. The starting material for the synthesis is represented by commercial available hydroxy-androgens, which are further modified. First, the hydroxyl group is attached to the spacer and then connected to the desired imidazole or the protected primary amine. The above described derivatives will be utilized for development of analytical kits for a determination of the free steroid hormone.
Trvalý link: http://hdl.handle.net/11104/0289610