Synthesis of water-soluble star polymers based on cyclodextrins

0496680 - ÚMCH 2019 RIV CZ eng J - Článek v odborném periodiku
Kotrchová, Lenka - Etrych, Tomáš
Synthesis of water-soluble star polymers based on cyclodextrins.
Physiological Research. Roč. 67, Suppl. 2 (2018), S357-S365. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MŠMT(CZ) LQ1604
Institucionální podpora: RVO:61389013
Klíčová slova: HPMA copolymers * RAFT polymerization * star polymers
Obor OECD: Polymer science
Impakt faktor: 1.701, rok: 2018
http://www.biomed.cas.cz/physiolres/pdf/67/67_S357.pdf

Novel star polymers based on the water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer and cyclodextrin were synthesized and the physico-chemical behavior of these precursors was studied. Semitelechelic HPMA copolymers were grafted onto the cyclodextrin core, thus forming star-like structure. Both prepared systems were designed as possible polymer carriers for the controlled release of cytostatic drugs, which after the drug release and degradation will be eliminated from the organism. Two synthesis approaches were used to obtain similar polymer carriers with different degradation rates. All the polymers were prepared by reversible additionfragmentation chain-transfer polymerization, which guarantees low dispersity of the prepared systems.
Trvalý link: http://hdl.handle.net/11104/0289367