Silica-based nanoparticles are efficient delivery systems for temoporfin

0495928 - ÚMG 2019 RIV NL eng J - Článek v odborném periodiku
Brezaniova, I. - Záruba, K. - Králová, Jarmila - Sinica, A. - Adámková, H. - Ulbrich, P. - Pouckova, P. - Hrubý, Martin - Štěpánek, Petr - Král, V.
Silica-based nanoparticles are efficient delivery systems for temoporfin.
Photodiagnosis and Photodynamic Therapy. Roč. 21, Marz (2018), s. 275-284. ISSN 1572-1000. E-ISSN 1873-1597
Grant CEP: GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT(CZ) LM2015064; GA ČR(CZ) GA17-02448S; GA ČR(CZ) GA16-03156S; GA MZd(CZ) NV16-30544A; GA MŠMT(CZ) LO1304; GA MŠMT(CZ) LQ1604
Institucionální podpora: RVO:68378050 ; RVO:61389013
Klíčová slova: Photodynamic therapy * Drug delivery * Blood-brain barrier * Silica nanoparticles * Temoporfin
Obor OECD: Cell biology; Polymer science (UMCH-V)
Impakt faktor: 2.589, rok: 2018

Background Drug targeting using functionalized nanoparticles to advance their transport to the dedicated site became a new standard in novel anticancer methods Anticancer photodynamic therapy also takes benefit from using nanoparticles by means of increasing targeting efficiency and decreased side effect. With this in mind, the silica-based nanoparticles, as drug delivery systems for the second-generation photosensitizer 5,10,15,20-tetrakis(m-hydroxyphenyl) chlorin (temoporfin) were developed.
Trvalý link: http://hdl.handle.net/11104/0288801