Počet záznamů: 1  

Combined antitumor effect of surface-modified superparamagnetic maghemite nanoparticles and a vitamin E derivative on experimental Walker-256 mammary gland carcinosarcoma

  1. 1.
    0494217 - ÚMCH 2020 RIV NL eng J - Článek v odborném periodiku
    Zasońska, Beata Anna - Pustovyy, V. I. - Babinskiy, A. V. - Palyvoda, O. M. - Chekhun, V. F. - Todor, I. - Petrovský, Eduard - Kuzmenko, O. I. - Horák, Daniel
    Combined antitumor effect of surface-modified superparamagnetic maghemite nanoparticles and a vitamin E derivative on experimental Walker-256 mammary gland carcinosarcoma.
    Journal of Magnetism and Magnetic Materials. Roč. 471, 1 February (2019), s. 381-387. ISSN 0304-8853. E-ISSN 1873-4766
    Grant CEP: GA ČR(CZ) GA17-04918S
    Institucionální podpora: RVO:61389013 ; RVO:67985530
    Klíčová slova: superparamagnetic * nanoparticles * α-tocopherol
    Obor OECD: Polymer science; Physical geography (GFU-E)
    Impakt faktor: 2.717, rok: 2019
    Způsob publikování: Omezený přístup
    https://www.sciencedirect.com/science/article/pii/S0304885318312216?via%3Dihub

    In a search for efficient anti-tumor agent, silica-coated superparamagnetic nanoparticles were designed and used in combination with vitamin E derivative as a potential new tool for anticancer treatment. The particles were characterized by numerous techniques, such as transmission electron microscopy and dynamic light scattering to determine the particle morphology and size both in dry state and water, atomic absorption spectroscopy to analyze the iron content, Fourier-transform infrared spectroscopy to confirm the presence of the functional groups, and vibrating sample magnetometry to determine the magnetic properties and content of maghemite. The next aim was to assess effect of the nanoparticles on suppression of experimental mammary gland carcinosarcoma W-256. Strong antitumor effect was achieved only with combined application of γ-Fe2O3@SiO2 and acetate derivative of α-tocopherol (Toc-6-Ac) resulting in 58% of tumor volume reduction. The results were compared with those obtained with poly(N,N-dimethylacrylamide)-coated iron oxide particles described earlier.
    Trvalý link: http://hdl.handle.net/11104/0287706

     
     
Počet záznamů: 1  

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