Počet záznamů: 1  

'Sweet Flavonoids': Glycosidase-Catalyzed Modifications

  1. 1.
    0493887 - MBÚ 2019 RIV CH eng J - Článek v odborném periodiku
    Slámová, Kristýna - Kapešová, Jana - Valentová, Kateřina
    'Sweet Flavonoids': Glycosidase-Catalyzed Modifications.
    International Journal of Molecular Sciences. Roč. 19, č. 7 (2018), č. článku 2126. E-ISSN 1422-0067
    Grant CEP: GA MŠMT(CZ) LTC18003
    Institucionální podpora: RVO:61388971
    Klíčová slova: enzymatic hydrolysis * quercetin * hesperetin
    Obor OECD: Biochemistry and molecular biology
    Impakt faktor: 4.183, rok: 2018

    Natural flavonoids, especially in their glycosylated forms, are the most abundant phenolic compounds found in plants, fruit, and vegetables. They exhibit a large variety of beneficial physiological effects, which makes them generally interesting in a broad spectrum of scientific areas. In this review, we focus on recent advances in the modifications of the glycosidic parts of various flavonoids employing glycosidases, covering both selective trimming of the sugar moieties and glycosylation of flavonoid aglycones by natural and mutant glycosidases. Glycosylation of flavonoids strongly enhances their water solubility and thus increases their bioavailability. Antioxidant and most biological activities are usually less pronounced in glycosides, but some specific bioactivities are enhanced. The presence of L-rhamnose (6-deoxy-alpha-L-mannopyranose) in rhamnosides, rutinosides (rutin, hesperidin) and neohesperidosides (naringin) plays an important role in properties of flavonoid glycosides, which can be considered as 'pro-drugs'. The natural hydrolytic activity of glycosidases is widely employed in biotechnological deglycosylation processes producing respective aglycones or partially deglycosylated flavonoids. Moreover, deglycosylation is quite commonly used in the food industry aiming at the improvement of sensoric properties of beverages such as debittering of citrus juices or enhancement of wine aromas. Therefore, natural and mutant glycosidases are excellent tools for modifications of flavonoid glycosides.
    Trvalý link: http://hdl.handle.net/11104/0287168

     
     
Počet záznamů: 1  

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