Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

0493722 - ÚEM 2019 RIV GB eng J - Článek v odborném periodiku
Klein, A. P. - Wolpin, B. M. - Risch, H. A. - Stolzenberg-Solomon, R.Z. - Mocci, E. - Zhang, M. - Canzian, F. - Childs, E.J. - Hoskins, J.W. - Jermusyk, A. - Zhong, J. - Chen, F. - Albanes, D. - Andreotti, G. - Arslan, A. A. - Babic, A. - Bamlet, W.R. - Beane-Freeman, L. - Berndt, S. I. - Blackford, A. - Borges, M. - Borgida, A. - Bracci, P. M. - Brais, L. - Brennan, P. - Brenner, H. - Bueno-de-Mesqiuta, B. - Buring, J. - Campa, D. - Capurso, G. - Cavestro, G.M. - Chaffee, K.G. - Chung, C.C. - Cleary, S. - Cotterchio, M. - Dijk, F. - Duell, E. J. - Foretová, L. - Fuchs, Ch. - Funel, N. - Gallinger, S. - Gaziano, J. M. - Gazouli, M. - Giles, G.G. - Giovannucci, E. - Goggins, M. - Goodman, P. J. - Hackert, T. - Haiman, Ch. A. - Hartge, P. - Hasan, M. - Hegyi, P. - Helzlsouer, K. J. - Herman, J. - Holcatová, I. - Holly, E. A. - Hoover, R. - Hung, R.J. - Jacobs, E. J. - Jamroziak, K. - Janout, V. - Kaaks, R. - Khaw, K. T. - Klein, E. A. - Kogevinas, M. - Kooperberg, Ch. - Kulke, M. H. - Kupcinskas, J. - Kurtz, R.J. - Laheru, D. - Landi, S. - Lawlor, R.T. - Lee, I.M. - LeMarchand, L. - Lu, L. - Malats, N. - Mambrini, A. - Mannisto, S. - Milne, R. L. - Mohelníková-Duchoňová, B. - Neale, R.E. - Neoptolemos, J.P. - Oberg, A.L. - Olson, S.H. - Orlow, I. - Pasquali, C. - Patel, A. V. - Peters, U. - Pezzilli, R. - Porta, M. - Real, F. X. - Rothman, N. - Scelo, G. - Sesso, H. D. - Severi, G. - Shu, X. O. - Silverman, D. - Smith, J.P. - Souček, P. - Sund, M. - Talar-Wojnarowska, R. - Tavano, F. - Thornquist, M. - Tobias, G. S. - Van Den Eeden, S.K. - Vashist, Y. - Visvanathan, K. - Vodička, Pavel - Wactawski-Wende, J. - Wang, Z.M. - Wentzensen, N. - White, E. - Yu, H. - Yu, K. - Zeleniuch-Jacquotte, A. - Zheng, W. - Kraft, P. - Li, D.H. - Chanock, S. - Obazee, O. - Petersen, G.M. - Amundadottir, L. T.
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Nature Communications. Roč. 9, feb. (2018), s. 556. E-ISSN 2041-1723
Grant CEP: GA ČR(CZ) GAP301/12/1734
Institucionální podpora: RVO:68378041
Klíčová slova: body-mass index * association analyses * gene-expression
Obor OECD: Gastroenterology and hepatology
Impakt faktor: 11.878, rok: 2018

In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 x 10(-8)). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PAN-DoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 x 10(-14)), rs2941471 at 8q21.11 (HNF4G, P = 6.60 x 10(-10)), rs4795218 at 17q12 (HNF1B, P = 1.32 x 10(-8)), and rs1517037 at 18q21.32 (GRP, P = 3.28 x 10(-8)). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
Trvalý link: http://hdl.handle.net/11104/0287155