Widespread evolutionary crosstalk among protein domains in the context of multi- domain proteins

0493595 - ÚOCHB 2019 RIV US eng J - Článek v odborném periodiku
Jakubec, Dávid - Kratochvíl, Miroslav - Vymětal, Jiří - Vondrášek, Jiří
Widespread evolutionary crosstalk among protein domains in the context of multi- domain proteins.
PLoS ONE. Roč. 13, č. 8 (2018), č. článku e0203085. ISSN 1932-6203. E-ISSN 1932-6203
Grant CEP: GA MŠMT(CZ) LM2015047
Institucionální podpora: RVO:61388963
Klíčová slova: direct-coupling analysis * sequence alignments * multidomain proteins
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 2.776, rok: 2018
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203085

Domains are distinct units within proteins that typically can fold independently into recognizable three-dimensional structures to facilitate their functions. The structural and functional independence of protein domains is reflected by their apparent modularity in the context of multi-domain proteins. In this work, we examined the coupling of evolution of domain sequences co-occurring within multi-domain proteins to see if it proceeds independently, or in a coordinated manner. We used continuous information theory measures to assess the extent of correlated mutations among domains in multi-domain proteins from organisms across the tree of life. In all multi-domain architectures we examined, domains co-occurring within protein sequences had to some degree undergone concerted evolution. This finding challenges the notion of complete modularity and independence of protein domains, providing new perspective on the evolution of protein sequence and function.
Trvalý link: http://hdl.handle.net/11104/0286933