Host-Guest Chemistry of Carboranes: Synthesis of Carboxylate Derivatives and Their Binding to Cyclodextrins

0493265 - ÚACH 2019 RIV DE eng J - Článek v odborném periodiku
Nekvinda, Jan - Grüner, Bohumír - Gabel, D. - Nau, W. M. - Assaf, K. I.
Host-Guest Chemistry of Carboranes: Synthesis of Carboxylate Derivatives and Their Binding to Cyclodextrins.
Chemistry - A European Journal. Roč. 24, č. 49 (2018), s. 12970-12975. ISSN 0947-6539. E-ISSN 1521-3765
Grant ostatní: AV ČR(CZ) DAAD-17-22
Program: Bilaterální spolupráce
Institucionální podpora: RVO:61388980
Klíčová slova: boron * cluster compounds * carboranes * host-guest systems * hydrophobic effect
Obor OECD: Inorganic and nuclear chemistry
Impakt faktor: 5.160, rok: 2018

Polyhedral carboxymethyl carborane (C2B10H12) derivatives, including mono- and disubstituted o-, m-, and p-isomers, have been synthesized. Supramolecular host-guest complexation of these derivatives with cyclodextrins (CDs, namely, alpha-, beta-, and gamma-CD) has been investigated in water. The globular structure of the carborane binding moiety and its hydrophobic character qualify it as an ideal recognition site to form stable inclusion complexes with macrocyclic host molecules in aqueous solution. The measured binding affinities for the carborane derivatives were in the millimolar range (K-a=10(3)-10(4)m(-1)) with differently sized CDs, and preferential binding to beta-CD.
Trvalý link: http://hdl.handle.net/11104/0286651


Vědecká data: Wiley onlinelibrary