Role of adipokinetic hormone during starvation in Drosophila

0492457 - BC 2019 RIV GB eng J - Článek v odborném periodiku
Mochanová, Michaela - Tomčala, Aleš - Svobodová, Zdeňka - Kodrík, Dalibor
Role of adipokinetic hormone during starvation in Drosophila.
Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology. Roč. 226, DEC 01 (2018), s. 26-35. ISSN 1096-4959. E-ISSN 1879-1107
Grant CEP: GA ČR(CZ) GA17-03253S; GA ČR(CZ) GBP501/12/G055
Institucionální podpora: RVO:60077344
Klíčová slova: Drosophila melanogaster mutants * adipokinetic hormone * metabolism
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 1.990, rok: 2018
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S109649591830099X?via%3Dihub

The role of adipokinetic hormone (AKH) in maintaining the levels of basic nutrients was studied using Drosophila mutants. Our results showed lipids as the main energy reserve, and their physiological level and metabolism were shown to be under the control of AKH. AKH abundance in the body resulted in lower levels of triacylglycerols and diacylglycerols than in the controls, interestingly, there was a disproportional representation of fatty acids in triacylglycerols and diacylglycerols. AKH-deficient flies were more resistant while AKH-abundant flies were more sensitive to starvation, females were found to be more resistant than males probably due to higher body mass and higher amount of nutrients. However, in accordance with the level of all nutrients, that of AKH also gradually decreased with prolonged starvation.
Trvalý link: http://hdl.handle.net/11104/0291444