The Paper that Restarted Modern Central Nervous System Axon Regeneration Research

0492416 - ÚEM 2019 RIV GB eng J - Článek v odborném periodiku
Fawcett, James
The Paper that Restarted Modern Central Nervous System Axon Regeneration Research.
Trends in Neurosciences. Roč. 41, č. 5 (2018), s. 239-242. ISSN 0166-2236. E-ISSN 1878-108X
Grant CEP: GA MŠMT(CZ) EF15_003/0000419
Institucionální podpora: RVO:68378041
Klíčová slova: spinal-cord-injury * plasticity * cells
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 12.314, rok: 2018
Způsob publikování: Omezený přístup
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(18)30061-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0166223618300614%3Fshowall%3Dtrue

Spinal cord repair research appeared to have run out of new ideas in the 1970s. In a 1981 paper, the Aguayo Laboratory revisited an experiment by Tello and Cajal that suggestedthat central nervous system (CNS) axons could regenerate into peripheral nerve grafts. Using modern axon tracing methods, David and Aguayo showed that axons from neurons in the spinal cord could regenerate for long distances within peripheral nervous system (PNS) grafts, but not back into the CNS. This proved that damaged CNS tissue is inhibitory to axon regeneration while PNS tissue is permissive. The experiment sparked a research revival, leading to the identification of many inhibitory molecules that block axon growth in the mature CNS.
Trvalý link: http://hdl.handle.net/11104/0285964