Experimental Enteric Bacterial Infections in Pigs

0492008 - MBÚ 2019 RIV US eng J - Článek v odborném periodiku
Šplíchal, Igor - Šplíchalová, Alla
Experimental Enteric Bacterial Infections in Pigs.
Journal of Infectious Diseases. Roč. 218, č. 3 (2018), s. 504-505. ISSN 0022-1899. E-ISSN 1537-6613
Grant CEP: GA ČR GA13-14736S; GA ČR GA13-08803S
Institucionální podpora: RVO:61388971
Klíčová slova: Enteric infection * intestinal barrier * claudins
Obor OECD: Immunology
Impakt faktor: 5.045, rok: 2018

It would be useful at experimental enteric bacterial infections in pigs to evaluate cytokines (1) local intestinal levels of the chemokine interleukin 8 (low levels show a protective role via attraction and activation of neutrophils, and high levels indicate a cytokine storm), (2) systemic levels of the regulatory cytokine interleukin 10 (its systemic appearance predicts death), (3) both local and systemic levels of the inflammatory cytokine tumor necrosis factor α (a general inflammatory marker high levels indicate a cytokine storm), and (4) local detection of the alarmin high mobility group box 1 (a marker of severity of enteric infection).
Trvalý link: http://hdl.handle.net/11104/0285599