Scedosporium and Lomentospora: an updated overview of underrated opportunists

0491889 - MBÚ 2019 RIV GB eng J - Článek v odborném periodiku
Havlíček, Vladimír … celkem 32 autorů
Scedosporium and Lomentospora: an updated overview of underrated opportunists.
Medical Mycology. Roč. 56, Supplement 1 (2018), s. 102-125. ISSN 1369-3786. E-ISSN 1460-2709
Grant CEP: GA ČR(CZ) GA16-20229S
Institucionální podpora: RVO:61388971
Klíčová slova: fungi * pathogen * infection
Obor OECD: Microbiology
Impakt faktor: 2.851, rok: 2018

Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.
Trvalý link: http://hdl.handle.net/11104/0285492