Nanomaterials in Biomedical research

0491794 - ÚEM 2019 RIV CZ eng M - Část monografie knihy
Krulová, Magdaléna - Hájková, Michaela - Javorková, Eliška
Immunosuppressive Effects of Mesenchymal Stem Cells Applied on Nanofiber Scaffolds in Combination with a Local Immunosuppression in a Model of Skin Transplantation.
Nanomaterials in Biomedical research. Praha 3: Proxima Tisk, s.r.o., 2017 - (Caraglia, M.), s. 101-105. ISBN 978-80-906655-5-2
Grant CEP: GA MŠMT(CZ) LO1309
Institucionální podpora: RVO:68378041
Klíčová slova: nanomaterials * cyclosporine A * transplantation * mesenchymal stem cells
Obor OECD: Cell biology

Allogeneic skin transplantation is usually associated with deleterious inflammatory reaction and requires administration of high doses of immunosuppressive drugs. Mesenchymal stem cells due to their regenerative and immunosuppressive properties offer a great potential for the cell therapy. We confirmed that locally applied mesenchymal stem cells in combination with cyclosporine A induce a switch in macrophage to a phenotype that reduce the local inflammatory reaction and support wound healing
Trvalý link: http://hdl.handle.net/11104/0285825