Xanthones content in swertia multicaulis D. Don from Nepal

0490943 - ÚVGZ 2019 RIV CH eng J - Článek v odborném periodiku
Timsina, Binu - Kindlmann, Pavel - Rokaya, Maan Bahadur - Vrchotová, Naděžda - Tříska, Jan - Horník, Štěpán - Sýkora, Jan
Xanthones content in swertia multicaulis D. Don from Nepal.
Molecules. Roč. 23, č. 5 (2018), č. článku 1067. E-ISSN 1420-3049
Grant CEP: GA MŠMT(CZ) LO1415
Institucionální podpora: RVO:86652079 ; RVO:67985858
Klíčová slova: Gentianaceae * hplc * lc–ms * nmr * Phytochemistry * Secondary metabolites * Swertia
Obor OECD: Biodiversity conservation; Analytical chemistry (UCHP-M)
Impakt faktor: 3.060, rok: 2018

The medicinal plant Swertia multicaulis D. Don was collected in Rasuwa District (Nepal) and the xanthone content of its ethyl acetate extracts was studied. The total amount of xanthones in S. multicaulis determined by HPLC reaches almost 13 g of xanthones per 1 kg of dry matter. The identification of xanthones in S. multicaulis was achieved by a combination of HPLC, LC–MS and LC–NMR. The final assignment of the individual chemical structures was provided by NMR, supported by preparative HPLC. In eight chromatographic peaks, four major xanthones were identified—1,3-dihydroxy-5,8-dimethoxyxanthone, 1-hydroxy-3,5,8-trimethoxyxanthone, bellidifolin (1,5,8-tri-hydroxy-3-methoxyxanthone), and decussatin (1-hydroxy-3,7,8-trimethoxyxanthone).
Trvalý link: http://hdl.handle.net/11104/0285053